1.Cas No: 127294-77-3
4.Melting point : 199-200°C
5.Boiling point: 253.7ºC
6.Storage conditions: Store in a cool, dry place.
Application:An important intermediate for the synthesis of fluoroquinolone antibacterial drug balofloxacin.
Introduction:3-methylaminopiperidine (1) is an important intermediate for the synthesis of fluoroquinolone antibacterial drug balofloxacin. The literature uses γ-butyrolactone as the raw material and undergoes amination, hydrolysis, esterification, and bromine Ethyl acetate condensation, cyclization, ester hydrolysis and decarboxylation, reductive amination and hydrogenolysis debenzyl reaction to obtain 3-methylaminopiperidine, the Chemicalbook steps are long, and the total yield is low (only 11.5%). Use 3-aminopyridine (2) to obtain 3-methylaminopyridine (4) by formylation and reduction with lithium aluminum hydride; or condense with 2 and triethyl orthoformate and reduce with sodium borohydride to obtain 4,4. Reduction of Pd/C to prepare 3-methylaminopiperidine diacetate with total yields of 16% and 32%, respectively.
Category:Nitrogen ring;piperidine;intermediate;general reagent;baloxacin intermediate;pharmaceutical intermediate;Piperidine;Heterocyclic Compounds.
We are Princechem Pharmaceutical manufacturer pass 20 years experience. Types of chemical reactions in are etherification, ammoniation, chlorination, esterification, cyclization, hydrogenation and Grignard reaction, etc..Over the past 10 years, more than 400 catalog products were developed. In recent years, more than 40 kinds of key pharmaceutical intermediates have been developed, involving anti-cancer, cardiovascular, digestive system, mental diseases and other fields. It includes the key intermediates of API such as Quetiapine, Fluvaxamine, Erlotinib, Gefitinib, Sunitinib, Lapatinib, Rabeprazole and Lafutidine. For many years, we have been providing high quality pharmaceutical intermediates for many world-famous pharmaceutical companies.
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