Mainly engaged in the development and production of new pharmaceutical intermediates

lnvolved in anti-cancer, cardiovascular, mental diseases and other fields

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Hydrocortisone acetate

Product Name:

Hydrocortisone acetate (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;

11,17-Dihydroxy-3,20-dioxopregn-4-en-21-ylacetate;

11-beta,17-alpha-dihydroxy-21-acetoxypregesterone;

11beta17alpha-Dihydroxy-21-acetoxypregesterone;

17-alpha-hydrocorticosterone21-acetate;

17alpha-Hydrocorticosterone-21-acetate;

Cortisone Acetate EP Impurity A(Hydrocortisone Acetate);

HydrocortisoneImpurity3(Hydrocortisone EP Impurity C)


Product Features

1.Cas No: 50-03-3
2.Molecular formula: C23H32O6
3. Chemical Structure

detail

4.Melting point : 223 °C (dec.)(lit.)
5.Boiling point: 446.1°C (rough estimate)
6.Density: d420 1.289
7.Refractive index:1.4593 (estimate)
8.Storage conditions: 0-6°C

DescriptionHydrocortisone acetate (11 β、 seventeen α、 21-trihydroxypregesterone-4-3,20-dione-21-acetate) is a corticosteroid drug, which has many pharmacological effects, such as anti-inflammatory, immunosuppression, anti-toxic and anti shock. 11 in the structure of steroidal chemicals β- Hydroxyl group is a necessary group for anti-inflammatory drugs. How to introduce 11 in the preparation of hydrocortisone acetate β- Hydroxyl group is the key step of the whole process. There are two main processes: microbial transformation and chemical method.

ApplicationHydrocortisone acetate is mainly used in the treatment of rheumatoid arthritis, rheumatic fever, gout, bronchial asthma and so on. The injection can be used for tuberculous or purulent meningitis, tuberculous pleurisy, purulent chest, arthritis, tenosynovitis, tendon strain, sprain, prurigo nodularis, lichen planus, etc. Eye drops are used for all kinds of ophthalmitis. Cream for allergic or seborrheic dermatitis, pruritus, etc.

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We are Princechem Pharmaceutical manufacturer pass 20 years experience.  Types of chemical reactions in are etherification, ammoniation, chlorination, esterification, cyclization, hydrogenation and Grignard reaction, etc..Over the past 10 years, more than 400 catalog products were developed. In recent years, more than 40 kinds of key pharmaceutical intermediates have been developed, involving anti-cancer, cardiovascular, digestive system, mental diseases and other fields. It includes the key intermediates of API such as Quetiapine, Fluvaxamine, Erlotinib, Gefitinib, Sunitinib, Lapatinib, Rabeprazole and Lafutidine. For many years, we have been providing high quality pharmaceutical intermediates for many world-famous pharmaceutical companies.

HI-Tech Enterprise was honored to YPC in 2011. The company adheres to scientific and technological innovation and has more than 10 authorized invention patents.

YPC insists on using the international standard management systems to promote our managements and have established the systems of ISO9001:2000, ISO14001:2004 and OHS18001:1999. Over the past few years, it has passed on-site audits by more than 20 international and domestic pharmaceutical companies.

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