Mainly engaged in the development and production of new pharmaceutical intermediates

lnvolved in anti-cancer, cardiovascular, mental diseases and other fields



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Product Features

1.Cas No: 50679-08-8.
2.Molecular formula: C32H41NO2.
3.Chemical Structure


4.Melting point : 145-152 °C
5.Boiling point: 572.76°C (rough estimate)
6.Density: 1.0488 (rough estimate)
7.Refractive index: 1.6310 (estimate)
8. Storage conditions: 2-8°C

Chemical propertyTerfenadine is crystallizes from acetone, melting point 146.5 ~ 148.5 ℃; There are three crystal forms: melting point 149-152 ℃, melting point 146-148 ℃, melting point 142-144 ℃. Solubility at 30 ℃ (g / 100ml): water 0.001, ethanol 3.780, methanol 3.750, hexane 0.034, 0.1mol/l hydrochloric acid 0.012, 0.1 mol.L citric acid 0.110, 0.1mol/l tartaric acid 0.045. UV maximum absorption (methanol): 260nm (a660.4)( Ethanol: 260nm (a671.4)( Dichloromethane): 260nm (a762.2). Acute toxicity LD50 rats, mice, guinea pigs (mg / kg): all > 2000 orally.

ApplicationThe Terfenadine new antihistamines have specific antagonistic effect on peripheral H1 receptor, and have no anti serotonin, anticholinergic and anti adrenergic effects. It is suitable for the treatment of seasonal allergic rhinitis (pollinosis), perennial allergic rhinitis, acute and chronic urticaria, etc.

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We are Princechem Pharmaceutical manufacturer pass 20 years experience.  Types of chemical reactions in are etherification, ammoniation, chlorination, esterification, cyclization, hydrogenation and Grignard reaction, etc..Over the past 10 years, more than 400 catalog products were developed. In recent years, more than 40 kinds of key pharmaceutical intermediates have been developed, involving anti-cancer, cardiovascular, digestive system, mental diseases and other fields. It includes the key intermediates of API such as Quetiapine, Fluvaxamine, Erlotinib, Gefitinib, Sunitinib, Lapatinib, Rabeprazole and Lafutidine. For many years, we have been providing high quality pharmaceutical intermediates for many world-famous pharmaceutical companies.

HI-Tech Enterprise was honored to YPC in 2011. The company adheres to scientific and technological innovation and has more than 10 authorized invention patents.

YPC insists on using the international standard management systems to promote our managements and have established the systems of ISO9001:2000, ISO14001:2004 and OHS18001:1999. Over the past few years, it has passed on-site audits by more than 20 international and domestic pharmaceutical companies.

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